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Type 4 Renal Tubular Acidosis Title: Ñ Type 4 Renal Tubular Acidosis Pathogenesis Causes KUS Chronic renal disorders such as: Ñ Diabetes mellitus Ñ Tubulointerstitial disease Drugs Ñ NSAIDs Ñ ACE inhibitors Ñ Beta-blockers Ñ Potassium sparing diuretics Ñ Aldosterone antagonists E&M Ñ Addison’s disease gives a similar picture Pathophysiology Ñ Plasma renin and aldosterone low Ñ Do not rise in response to stimulation Clinical Features KUS Ñ Metabolic acidosis Investigations Fluids Blood Biochemistry Ñ Acidosis Ñ Hyperchloraemia Ñ Hyperkalaemia Management Control Drugs Ñ Fludrocortisone
Type 4 Renal Tubular Acidosis
Title:
Ñ Type 4 Renal Tubular Acidosis
Pathogenesis
Causes
KUS
Chronic renal disorders such as:
Ñ Diabetes mellitus
Ñ Tubulointerstitial disease
Drugs
Ñ NSAIDs
Ñ ACE inhibitors
Ñ Beta-blockers
Ñ Potassium sparing diuretics
Ñ Aldosterone antagonists
E&M
Ñ Addison’s disease gives a similar picture
Pathophysiology
Ñ Plasma renin and aldosterone low
Ñ Do not rise in response to stimulation
Clinical Features
Ñ Metabolic acidosis
Investigations
Fluids
Blood
Biochemistry
Ñ Acidosis
Ñ Hyperchloraemia
Ñ Hyperkalaemia
Management
Control
Ñ Fludrocortisone
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