Home
Keys to Success in Medicine
Cardiovascular System
Respiratory System
Locomotor System
Endocrine and Metabolic System
Kidneys and Urinary System
Gastrointestinal Tract
Central Nervous System
Haematological System
Integumental System
Reproductive and Genital System
Recommended Reading
Forum
Links

amazon astore

ydr

aces for paces

Polyarteritis Nodosa

Title               

Ñ    Polyarteritis Nodosa

Definition

Ñ    Vasculitis

Ñ    Involves medium sized vessels

Pathogenesis

Causes

Ñ    Not known

Ñ    Occasionally associated with Hepatitis B

Pathological Process

Ñ    Fibrinoid necrosis of vessel walls

Ñ    Formation of microaneurysms

Ñ    Thrombosis

Ñ    Infarction

Clinical Features

History

Sex and Age

Ñ    Commoner in middle-aged men

E&M

Ñ    Fever

Ñ    Malaise

Ñ    Weight loss

GIT

Ñ    Abdominal pain:

Due to infarction of viscera

May simulate cholecystitis, pancreatitis, appendicitis

Ñ    Gastrointestinal haemorrhage

KUS

Ñ    Haematuria

Ñ    Proteinuria

LMS

Ñ    Myalgia

Examination

IS

Ñ    Subcutaneous haemorrhage

Ñ    Gangrene

Ñ    Livedo reticularis

CVS

Ñ    Myocardial infarction

Ñ    Heart failure

Ñ    Pericarditis

RS

Ñ    Involvement rare

GIT

Ñ    Mimic acute abdomen

KUS

Ñ    Hypertension

Ñ    Acute renal failure

Ñ    Chronic renal failure

HS

Ñ    Anaemia

CNS

Ñ    Mononeuritis multiplex

Investigations

Fluids

Blood

Haematology

Ñ    Anaemia

Ñ    Leucocytosis

Ñ    ESR:

Elevated

Imaging

Angiography

Ñ    Demonstrates microaneurysms in hepatic, intestinal, renal vessels

Electrophysiology

ECG

Ñ    Changes due to ischaemia

Tissue Diagnosis

Biopsy

Ñ    Affected organs show fibrinoid necrosis of vessel walls, microaneurysms, thrombosis, infarction

Management

Control

Drugs

Ñ    Steroids

Ñ    Immunosuppressives:

Azathioprine

[ Back ] [ Up ] [ Next ]

[Up]