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Title: Brugada Syndrome Definition: ♥ Syncopal episodes and sudden death ª Associated with ECG changes: Right bundle branch block ST segment elevation in leads V1 – V3 Aetiology: ¨ Autosomal dominant inheritance Pathogenesis § Abnormality in the cardiac sodium channel ♥ Episodic polymorphic ventricular tachycardia or ventricular fibrillation Clinical Features: History: ª Rare in the west, more common in South East Asia ¨ More common in young men CVS: § Syncope ♥ Sudden death Examination: ª No abnormalities on examination Investigations: Electrophysiology: ECG ¨ Right bundle branch block § J point elevation and concave ST elevation in leads V1-V3 ♥ If the ECG is normal the changes may be provoked by administration of ajmaline, procainamide, flecainide Management: Control Surgery: ª Implantable cardioverter defibrillator Prognosis: ¨ Poor without treatment § With treatment mortality reduced to 0 %
Title:
Brugada Syndrome
Definition:
♥ Syncopal episodes and sudden death
ª Associated with ECG changes:
Right bundle branch block
ST segment elevation in leads V1 – V3
Aetiology:
¨ Autosomal dominant inheritance
§ Abnormality in the cardiac sodium channel
♥ Episodic polymorphic ventricular tachycardia or ventricular fibrillation
Clinical Features:
History:
ª Rare in the west, more common in South East Asia
¨ More common in young men
CVS:
§ Syncope
♥ Sudden death
Examination:
ª No abnormalities on examination
Investigations:
Electrophysiology:
ECG
¨ Right bundle branch block
§ J point elevation and concave ST elevation in leads V1-V3
♥ If the ECG is normal the changes may be provoked by administration of ajmaline, procainamide, flecainide
Management:
Control
Surgery:
ª Implantable cardioverter defibrillator
Prognosis:
¨ Poor without treatment
§ With treatment mortality reduced to 0 %
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